3LJ2

IRE1 complexed with JAK Inhibitor I

Summary for 3LJ2

Entry DOI	10.2210/pdb3lj2/pdb
Related	3LJ0 3LJ1
Descriptor	Serine/threonine-protein kinase/endoribonuclease IRE1, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE (2 entities in total)
Functional Keywords	kinase, kinase inhibitor, nuclease activator, atp-binding, endoplasmic reticulum, glycoprotein, hydrolase, magnesium, membrane, metal-binding, multifunctional enzyme, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transcription, transcription regulation, transferase, transmembrane, unfolded protein response
Biological source	Saccharomyces cerevisiae (yeast)
Cellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein: P32361
Total number of polymer chains	2
Total formula weight	101175.35
Authors	Lee, K.P.K.,Sicheri, F. (deposition date: 2010-01-25, release date: 2010-05-12, Last modification date: 2023-09-06)
Primary citation	Wiseman, R.L.,Zhang, Y.,Lee, K.P.,Harding, H.P.,Haynes, C.M.,Price, J.,Sicheri, F.,Ron, D. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol.Cell, 38:291-304, 2010 Cited by PubMed: 20417606 DOI: 10.1016/j.molcel.2010.04.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.33 Å)

Structure validation