3LJ0

IRE1 complexed with ADP and Quercetin

Summary for 3LJ0

Entry DOI	10.2210/pdb3lj0/pdb
Related	3LJ1 3LJ2
Descriptor	Serine/threonine-protein kinase/endoribonuclease IRE1, MAGNESIUM ION, STRONTIUM ION, ... (5 entities in total)
Functional Keywords	kinase, flavonol, activator, dimer, atp-binding, endoplasmic reticulum, glycoprotein, hydrolase, magnesium, membrane, metal-binding, multifunctional enzyme, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transcription, transcription regulation, transferase, transmembrane, unfolded protein response
Biological source	Saccharomyces cerevisiae (yeast)
Cellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein: P32361
Total number of polymer chains	2
Total formula weight	102239.40
Authors	Lee, K.P.K.,Sicheri, F. (deposition date: 2010-01-25, release date: 2010-05-12, Last modification date: 2023-09-06)
Primary citation	Wiseman, R.L.,Zhang, Y.,Lee, K.P.,Harding, H.P.,Haynes, C.M.,Price, J.,Sicheri, F.,Ron, D. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol.Cell, 38:291-304, 2010 Cited by PubMed: 20417606 DOI: 10.1016/j.molcel.2010.04.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation