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3LEX

2F5 Epitope scaffold elicited anti-HIV-1 monoclonal antibody 11F10 in complex with HIV-1 GP41

Summary for 3LEX

Related3LES 3LEV 3LEY 1TJI 
Descriptor11f10 Antibody Heavy Chain, 11f10 Antibody Light Chain, Envelope glycoprotein gp41
Functional KeywordsHIV-1, GP-41, MONOCLONAL ANTIBODY, 2F5, SCAFFOLD, EPITOPE, TRANSPLANT, GRAFT, RE-ELCITATION, Envelope protein, IMMUNE SYSTEM, VACCINE DESIGN,IMMUNE SYSTEM
Biological sourceMus musculus (mouse)
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Total number of polymer chains6
Total molecular weight98334.47
Authors
Ofek, G.,Guenaga, F.J.,Schief, W.R.,Skinner, J.,Baker, D.,Wyatt, R.,Kwong, P.D. (deposition date: 2010-01-15, release date: 2010-09-29, modification date: 2010-11-24)
Primary citation
Ofek, G.,Guenaga, F.J.,Schief, W.R.,Skinner, J.,Baker, D.,Wyatt, R.,Kwong, P.D.
Elicitation of structure-specific antibodies by epitope scaffolds.
Proc.Natl.Acad.Sci.USA, 107:17880-17887, 2010
PubMed: 20876137
DOI: 10.1073/pnas.1004728107
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.97 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.19990.1%0.8%1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolutionDownload full validation report

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105097
entries available on 2014-12-17
00:00 UTC / 09:00 JST