3LEX

2F5 Epitope scaffold elicited anti-HIV-1 monoclonal antibody 11F10 in complex with HIV-1 GP41

Summary for 3LEX

Related3LES 3LEV 3LEY 1TJI
Descriptor11f10 Antibody Heavy Chain, 11f10 Antibody Light Chain, Envelope glycoprotein gp41
Functional Keywordshiv-1, gp-41, monoclonal antibody, 2f5, scaffold, epitope, transplant, graft, re-elcitation, envelope protein, immune system, vaccine design
Biological sourceMus musculus (mouse)
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Total number of polymer chains6
Total molecular weight98334.47
Authors
Ofek, G.,Guenaga, F.J.,Schief, W.R.,Skinner, J.,Baker, D.,Wyatt, R.,Kwong, P.D. (deposition date: 2010-01-15, release date: 2010-09-29, modification date: 2010-11-24)
Primary citation
Ofek, G.,Guenaga, F.J.,Schief, W.R.,Skinner, J.,Baker, D.,Wyatt, R.,Kwong, P.D.
Elicitation of structure-specific antibodies by epitope scaffolds.
Proc.Natl.Acad.Sci.USA, 107:17880-17887, 2010
PubMed: 20876137
DOI: 10.1073/pnas.1004728107
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.97 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.19990.1%0.8%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3lex
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Molmil generated image of 3lex
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Molmil generated image of 3lex
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More Biological unit images

Molmil generated image of 3lex
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Molmil generated image of 3lex
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Molmil generated image of 3lex
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3lex.pdb1.gz [76.44 KB])
Coordinate files for Biological unit (3lex.pdb2.gz [76.59 KB])
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