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3L4K

Topoisomerase II-DNA cleavage complex, metal-bound

Summary for 3L4K
Entry DOI10.2210/pdb3l4k/pdb
Related3L4J
DescriptorDNA topoisomerase 2, DNA (5'-D(P*CP*CP*TP*AP*CP*TP*GP*CP*TP*AP*C)-3'), DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3'), ... (8 entities in total)
Functional Keywordstopoisomerase, protein-dna complex, covalently linked complex, dna supercoiling, dna replication, atp-binding, dna-binding, isomerase, nucleotide-binding, nucleus, phosphoprotein, isomerase-dna complex, isomerase/dna
Biological sourceSaccharomyces cerevisiae (brewer's yeast,lager beer yeast,yeast)
Total number of polymer chains5
Total formula weight104469.91
Authors
Schmidt, B.H.,Burgin, A.B.,Deweese, J.E.,Osheroff, N.,Berger, J.M. (deposition date: 2009-12-20, release date: 2010-05-26, Last modification date: 2023-11-22)
Primary citationSchmidt, B.H.,Burgin, A.B.,Deweese, J.E.,Osheroff, N.,Berger, J.M.
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases.
Nature, 465:641-644, 2010
Cited by
PubMed: 20485342
DOI: 10.1038/nature08974
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.98 Å)
Structure validation

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