3IV2

Crystal structure of mature apo-Cathepsin L C25A mutant

Summary for 3IV2

Entry DOI	10.2210/pdb3iv2/pdb
Related	3K24
Descriptor	Cathepsin L1, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (6 entities in total)
Functional Keywords	protease, mutant, apo, disulfide bond, glycoprotein, hydrolase, lysosome, thiol protease, zymogen
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	49408.20
Authors	Adams-Cioaba, M.A.,Krupa, J.C.,Mort, J.S.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Min, J. (deposition date: 2009-08-31, release date: 2010-03-23, Last modification date: 2021-10-13)
Primary citation	Adams-Cioaba, M.A.,Krupa, J.C.,Xu, C.,Mort, J.S.,Min, J. Structural basis for the recognition and cleavage of histone H3 by cathepsin L. Nat Commun, 2:197-197, 2011 Cited by PubMed: 21326229 DOI: 10.1038/ncomms1204 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation