3K24

Crystal structure of mature apo-Cathepsin L C25A mutant in complex with Gln-Leu-Ala peptide

Summary for 3K24

• Entry DOI: 10.2210/pdb3k24/pdb
• Related: 3IV2
• Descriptor: Cathepsin L1, H3 peptide, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-6)-beta-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: co-crystal, substrate, protease, structural genomics, structural genomics consortium, sgc, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 50315.26

Authors

Adams-Cioaba, M.A.,Krupa, J.C.,Mort, J.S.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2009-09-29, release date: 2010-03-23, Last modification date: 2023-09-06)

• Primary citation: Adams-Cioaba, M.A.,Krupa, J.C.,Xu, C.,Mort, J.S.,Min, J.; Structural basis for the recognition and cleavage of histone H3 by cathepsin L.; Nat Commun, 2:197-197, 2011; PubMed: 21326229; DOI: 10.1038/ncomms1204

Experimental method

X-RAY DIFFRACTION (2.5 Å)