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3IMJ

Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic

Summary for 3IMJ
Entry DOI10.2210/pdb3imj/pdb
Related2HUW 3C7I 3IMD 3IN7 3IN8
Related PRD IDPRD_000632
DescriptorGrowth factor receptor-bound protein 2, (1R,2S,3R,1S',1S")Phosphoric acid mono(4-{2-[1-(1,2-dicarbamoylethylcarbamoyl)-3-carbamoylpropylcarbamoyl]-3-methylcarbamoylcyclopropyl}phenyl) ester (3 entities in total)
Functional Keywordsligand preorganization, peptide mimics, golgi apparatus, host-virus interaction, phosphoprotein, sh2 domain, sh3 domain, signaling protein-pseudopeptide ligand complex, signaling protein-peptide complex, signaling protein/peptide
Biological sourceHomo sapiens (human)
Cellular locationNucleus : P62993
Total number of polymer chains2
Total formula weight28600.07
Authors
Clements, J.H. (deposition date: 2009-08-10, release date: 2009-11-17, Last modification date: 2023-09-06)
Primary citationDelorbe, J.E.,Clements, J.H.,Teresk, M.G.,Benfield, A.P.,Plake, H.R.,Millspaugh, L.E.,Martin, S.F.
Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization.
J.Am.Chem.Soc., 131:16758-16770, 2009
Cited by
PubMed: 19886660
DOI: 10.1021/ja904698q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.02 Å)
Structure validation

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