3HO5

Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex

Summary for 3HO5

• Entry DOI: 10.2210/pdb3ho5/pdb
• Related: 3HO3 3HO4
• Descriptor: Hedgehog-interacting protein, Sonic hedgehog protein, ZINC ION, ... (4 entities in total)
• Functional Keywords: receptor ectodomain, six-bladed-propeller domain, egf domain, disulfide bond, calcium cation, zinc cation, cell membrane, egf-like domain, glycoprotein, membrane, secreted, autocatalytic cleavage, developmental protein, disease mutation, holoprosencephaly, hydrolase, lipoprotein, microphthalmia, palmitate, protease, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Peripheral membrane protein (By similarity). Isoform 2: Cytoplasm (Probable): Q96QV1; Sonic hedgehog protein C-product: Secreted, extracellular space (By similarity). Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor (By similarity): Q15465
• Total number of polymer chains: 3
• Total formula weight: 127507.95

Authors

Hymowitz, S.G.,Bosanac, I. (deposition date: 2009-06-01, release date: 2009-06-23, Last modification date: 2023-09-06)

• Primary citation: Bosanac, I.,Maun, H.R.,Scales, S.J.,Wen, X.,Lingel, A.,Bazan, J.F.,de Sauvage, F.J.,Hymowitz, S.G.,Lazarus, R.A.; The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.; Nat.Struct.Mol.Biol., 16:691-697, 2009; PubMed: 19561609; DOI: 10.1038/nsmb.1632

Experimental method

X-RAY DIFFRACTION (3.01 Å)