3HO5

Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Hedgehog-interacting protein	polymer	481	54087.2	2	UniProt (Q96QV1) Pfam (PF07995) Pfam (PF07974) In PDB	Homo sapiens (human)	HHIP, HIP
2	H	Sonic hedgehog protein	polymer	169	19122.5	1	UniProt (Q15465) Pfam (PF01085) In PDB	Homo sapiens (human)	SHH, HHG-1, Sonic hedgehog protein N-product, Sonic hedgehog protein C-product
3	A, H	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	H	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)

Sequence modifications

A, B: 193 - 667 (UniProt: Q96QV1)

PDB	External Database	Details
His 668	-	expression tag
His 669	-	expression tag
His 670	-	expression tag
His 671	-	expression tag
His 672	-	expression tag
His 673	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	127297.0
Non-Polymers*	Number of molecules	4
	Total formula weight	211.0
All*	Total formula weight	127507.9

*Water molecules are not included.