3HNC
Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP
Summary for 3HNC
Entry DOI | 10.2210/pdb3hnc/pdb |
Related | 3HND 3HNE 3HNF |
Descriptor | Ribonucleoside-diphosphate reductase large subunit, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | oxidoreductase, ribonucleotide reductase, allosteric enzyme, atp-binding, dna replication, nucleotide-binding |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P23921 |
Total number of polymer chains | 2 |
Total formula weight | 181947.37 |
Authors | Fairman, J.W.,Wijerathna, S.R.,Xu, H.,Dealwis, C.G. (deposition date: 2009-05-31, release date: 2011-02-23, Last modification date: 2024-02-21) |
Primary citation | Fairman, J.W.,Wijerathna, S.R.,Ahmad, M.F.,Xu, H.,Nakano, R.,Jha, S.,Prendergast, J.,Welin, R.M.,Flodin, S.,Roos, A.,Nordlund, P.,Li, Z.,Walz, T.,Dealwis, C.G. Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18:316-322, 2011 Cited by PubMed: 21336276DOI: 10.1038/nsmb.2007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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