3HNF

Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and dATP

Summary for 3HNF

Entry DOI	10.2210/pdb3hnf/pdb
Related	3HNC 3HND 3HNE
Descriptor	Ribonucleoside-diphosphate reductase large subunit, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ... (6 entities in total)
Functional Keywords	oxidoreductase, ribonucleotide reductase, allosteric enzyme, atp-binding, dna replication, nucleotide-binding
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P23921
Total number of polymer chains	2
Total formula weight	182246.43
Authors	Fairman, J.W.,Wijerathna, S.R.,Xu, H.,Dealwis, C.G. (deposition date: 2009-05-31, release date: 2011-02-23, Last modification date: 2023-09-06)
Primary citation	Fairman, J.W.,Wijerathna, S.R.,Ahmad, M.F.,Xu, H.,Nakano, R.,Jha, S.,Prendergast, J.,Welin, R.M.,Flodin, S.,Roos, A.,Nordlund, P.,Li, Z.,Walz, T.,Dealwis, C.G. Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18:316-322, 2011 Cited by PubMed: 21336276 DOI: 10.1038/nsmb.2007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.16 Å)

Structure validation