3HDM
Crystal structure of serum and glucocorticoid-regulated kinase 1 in complex with compound 1
Summary for 3HDM
Entry DOI | 10.2210/pdb3hdm/pdb |
Related | 3HDN |
Descriptor | Serine/threonine-protein kinase Sgk1, 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid (3 entities in total) |
Functional Keywords | agc protein kinase, apoptosis, atp-binding, endoplasmic reticulum, nucleotide-binding, nucleus, phosphorylation, serine/threonine-protein kinase, transferase, kinase, phosphoprotein |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 2: Cell membrane. Cytoplasm: O00141 |
Total number of polymer chains | 1 |
Total formula weight | 42617.66 |
Authors | Zhao, B.,Hammond, M. (deposition date: 2009-05-07, release date: 2009-06-30, Last modification date: 2021-10-13) |
Primary citation | Hammond, M.,Washburn, D.G.,Hoang, H.T.,Manns, S.,Frazee, J.S.,Nakamura, H.,Patterson, J.R.,Trizna, W.,Wu, C.,Azzarano, L.M.,Nagilla, R.,Nord, M.,Trejo, R.,Head, M.S.,Zhao, B.,Smallwood, A.M.,Hightower, K.,Laping, N.J.,Schnackenberg, C.G.,Thompson, S.K. Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors. Bioorg.Med.Chem.Lett., 19:4441-4445, 2009 Cited by PubMed: 19497745DOI: 10.1016/j.bmcl.2009.05.051 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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