3HDN

Crystal structure of serum and glucocorticoid-regulated kinase 1 in complex with compound 2

Summary for 3HDN

• Entry DOI: 10.2210/pdb3hdn/pdb
• Related: 3HDM
• Descriptor: Serine/threonine-protein kinase Sgk1, [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid (3 entities in total)
• Functional Keywords: agc protein kinase, apoptosis, atp-binding, endoplasmic reticulum, nucleotide-binding, nucleus, phosphorylation, serine/threonine-protein kinase, transferase, kinase, phosphoprotein
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 2: Cell membrane. Cytoplasm: O00141
• Total number of polymer chains: 1
• Total formula weight: 42681.74

Authors

Zhao, B.,Hammond, M. (deposition date: 2009-05-07, release date: 2009-06-30, Last modification date: 2024-02-21)

• Primary citation: Hammond, M.,Washburn, D.G.,Hoang, H.T.,Manns, S.,Frazee, J.S.,Nakamura, H.,Patterson, J.R.,Trizna, W.,Wu, C.,Azzarano, L.M.,Nagilla, R.,Nord, M.,Trejo, R.,Head, M.S.,Zhao, B.,Smallwood, A.M.,Hightower, K.,Laping, N.J.,Schnackenberg, C.G.,Thompson, S.K.; Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors.; Bioorg.Med.Chem.Lett., 19:4441-4445, 2009; PubMed: 19497745; DOI: 10.1016/j.bmcl.2009.05.051

Experimental method

X-RAY DIFFRACTION (3.1 Å)