3H8C
A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors (compound 14)
Summary for 3H8C
Entry DOI | 10.2210/pdb3h8c/pdb |
Related | 3H89 3H8B |
Descriptor | Cathepsin L1, N-(biphenyl-4-ylacetyl)-S-methyl-L-cysteinyl-D-arginyl-N-(2-phenylethyl)-L-phenylalaninamide (3 entities in total) |
Functional Keywords | cysteine proteases, cathepsin l, disulfide bond, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P07711 |
Total number of polymer chains | 2 |
Total formula weight | 49919.28 |
Authors | Tulsidas, S.R.,Chowdhury, S.F.,Kumar, S.,Joseph, L.,Purisima, E.O.,Sivaraman, J. (deposition date: 2009-04-29, release date: 2009-10-20, Last modification date: 2014-11-12) |
Primary citation | Shenoy, R.T.,Chowdhury, S.F.,Kumar, S.,Joseph, L.,Purisima, E.O.,Sivaraman, J. A Combined Crystallographic and Molecular Dynamics Study of Cathepsin L Retrobinding Inhibitors J.Med.Chem., 2009 Cited by PubMed: 19761244DOI: 10.1021/jm900596y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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