3H89

A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors(compound 4)

Summary for 3H89

Entry DOI	10.2210/pdb3h89/pdb
Related	3H8B 3H8C
Descriptor	Cathepsin L1, N~2~,N~6~-bis(biphenyl-4-ylacetyl)-L-lysyl-D-arginyl-N-(2-phenylethyl)-L-tyrosinamide (3 entities in total)
Functional Keywords	cysteine proteases, cathepsin l, disulfide bond, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P07711
Total number of polymer chains	6
Total formula weight	150893.21
Authors	Tulsidas, S.R.,Chowdhury, S.F.,Kumar, S.,Joseph, L.,Purisima, E.O.,Sivaraman, J. (deposition date: 2009-04-29, release date: 2009-10-20, Last modification date: 2014-02-05)
Primary citation	Shenoy, R.T.,Chowdhury, S.F.,Kumar, S.,Joseph, L.,Purisima, E.O.,Sivaraman, J. A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors J.Med.Chem., 52:6335-6346, 2009 Cited by PubMed: 19761244 DOI: 10.1021/jm900596y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation