3H0Y
Aurora A in complex with a bisanilinopyrimidine
Summary for 3H0Y
Entry DOI | 10.2210/pdb3h0y/pdb |
Related | 3COH 3H0Z 3H10 |
Descriptor | Serine/threonine-protein kinase 6, 2-chloro-N-[4-({5-fluoro-2-[(4-hydroxyphenyl)amino]pyrimidin-4-yl}amino)phenyl]benzamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | protein:inhibitor complex aurora-a, cell cycle, serine/threonine, protein kinase, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, centrosome: O14965 |
Total number of polymer chains | 1 |
Total formula weight | 31881.84 |
Authors | Wiesmann, C.,Ultsch, M.H.,Cochran, A.G. (deposition date: 2009-04-10, release date: 2009-07-07, Last modification date: 2024-02-21) |
Primary citation | Aliagas-Martin, I.,Burdick, D.,Corson, L.,Dotson, J.,Drummond, J.,Fields, C.,Huang, O.W.,Hunsaker, T.,Kleinheinz, T.,Krueger, E.,Liang, J.,Moffat, J.,Phillips, G.,Pulk, R.,Rawson, T.E.,Ultsch, M.,Walker, L.,Wiesmann, C.,Zhang, B.,Zhu, B.Y.,Cochran, A.G. A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J.Med.Chem., 52:3300-3307, 2009 Cited by PubMed: 19402633DOI: 10.1021/jm9000314 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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