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3H10

Aurora A inhibitor complex

Summary for 3H10
Entry DOI10.2210/pdb3h10/pdb
Related3COH 3H0Y 3H0Z
DescriptorSerine/threonine-protein kinase 6, 9-chloro-7-(2,6-difluorophenyl)-N-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-5H-pyrimido[5,4-d][2]benzazepin-2-amine (3 entities in total)
Functional Keywordsprotein:inhibitor complex aurora-a, cell cycle, serine/threonine, protein kinase, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, centrosome: O14965
Total number of polymer chains3
Total formula weight94820.20
Authors
Wiesmann, C.,Ultsch, M.H.,Cochran, A.G. (deposition date: 2009-04-10, release date: 2009-07-07, Last modification date: 2024-02-21)
Primary citationAliagas-Martin, I.,Burdick, D.,Corson, L.,Dotson, J.,Drummond, J.,Fields, C.,Huang, O.W.,Hunsaker, T.,Kleinheinz, T.,Krueger, E.,Liang, J.,Moffat, J.,Phillips, G.,Pulk, R.,Rawson, T.E.,Ultsch, M.,Walker, L.,Wiesmann, C.,Zhang, B.,Zhu, B.Y.,Cochran, A.G.
A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
J.Med.Chem., 52:3300-3307, 2009
Cited by
PubMed: 19402633
DOI: 10.1021/jm9000314
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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