3GMZ
Crystal of human arginase in complex with L-ornithine. Resolution 1.43 A.
Summary for 3GMZ
| Entry DOI | 10.2210/pdb3gmz/pdb |
| Related | 2ZAV 3GN0 |
| Descriptor | Arginase-1, MANGANESE (II) ION, L-ornithine, ... (4 entities in total) |
| Functional Keywords | ornithine binding, arginine metabolism, metal-binding, phosphoprotein, urea cycle, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P05089 |
| Total number of polymer chains | 2 |
| Total formula weight | 70043.83 |
| Authors | Di Costanzo, L.,Christianson, D.W. (deposition date: 2009-03-15, release date: 2010-01-26, Last modification date: 2023-09-06) |
| Primary citation | Ilies, M.,Di Costanzo, L.,Dowling, D.P.,Thorn, K.J.,Christianson, D.W. Binding of alpha,alpha-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design J.Med.Chem., 54:5432-5443, 2011 Cited by PubMed: 21728378DOI: 10.1021/jm200443b PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.43 Å) |
Structure validation
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