2ZAV

Arginase I (homo sapiens): native and unliganded structure at 1.70 A resolution

Summary for 2ZAV

Entry DOI	10.2210/pdb2zav/pdb
Related	2PHA
Descriptor	Arginase-1, MANGANESE (II) ION (3 entities in total)
Functional Keywords	manganese cluster coordination, proton wire, apical water, alternative splicing, arginine metabolism, cytoplasm, disease mutation, hydrolase, metal-binding, phosphorylation, polymorphism, urea cycle
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P05089
Total number of polymer chains	2
Total formula weight	69779.51
Authors	Di Costanzo, L.,Christianson, D.W. (deposition date: 2007-10-11, release date: 2007-10-30, Last modification date: 2023-11-01)
Primary citation	Di Costanzo, L.,Pique, M.E.,Christianson, D.W. Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster J.Am.Chem.Soc., 129:6388-6389, 2007 Cited by PubMed: 17469833 DOI: 10.1021/ja071567j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation