3G70

Design and Preparation of Potent, Non-Peptidic, Bioavailable Renin Inhibitors

Summary for 3G70

• Entry DOI: 10.2210/pdb3g70/pdb
• Related: 3G6Z 3g72
• Descriptor: Renin, (1R,5S)-7-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide, DIMETHYL SULFOXIDE, ... (5 entities in total)
• Functional Keywords: human renin, aspartyl protease, cleavage on pair of basic residues, disease mutation, glycoprotein, hydrolase, membrane, protease, secreted, zymogen
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P00797
• Total number of polymer chains: 2
• Total formula weight: 76702.95

Authors

Bezencon, O.,Bur, D.,Prade, L.,Weller, T.,Boss, C.,Fischli, W. (deposition date: 2009-02-09, release date: 2009-06-30, Last modification date: 2020-07-29)

• Primary citation: Bezencon, O.,Bur, D.,Weller, T.,Richard-Bildstein, S.,Remen, L.,Sifferlen, T.,Corminboeuf, O.,Grisostomi, C.,Boss, C.,Prade, L.,Delahaye, S.,Treiber, A.,Strickner, P.,Binkert, C.,Hess, P.,Steiner, B.,Fischli, W.; Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors; J.Med.Chem., 52:3689-3702, 2009; PubMed: 19358611; DOI: 10.1021/jm900022f

Experimental method

X-RAY DIFFRACTION (2 Å)