3G6Z

Design and Preparation of Potent, Non-Peptidic, Bioavailable Renin Inhibitors

Summary for 3G6Z

Entry DOI	10.2210/pdb3g6z/pdb
Related	3d91 3g70 3g72
Descriptor	Renin, (1R,5S)-N-cyclopropyl-7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-N-(2,3-dimethylbenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	renin human, aspartyl protease, cleavage on pair of basic residues, disease mutation, glycoprotein, hydrolase, membrane, protease, secreted, zymogen
Biological source	Homo sapiens (human)
Cellular location	Secreted: P00797
Total number of polymer chains	2
Total formula weight	76715.14
Authors	Bezencon, O.,Bur, D.,Prade, L.,Weller, T.,Boss, C.,Fischli, W. (deposition date: 2009-02-09, release date: 2009-06-30, Last modification date: 2020-07-29)
Primary citation	Bezencon, O.,Bur, D.,Weller, T.,Richard-Bildstein, S.,Remen, L.,Sifferlen, T.,Corminboeuf, O.,Grisostomi, C.,Boss, C.,Prade, L.,Delahaye, S.,Treiber, A.,Strickner, P.,Binkert, C.,Hess, P.,Steiner, B.,Fischli, W. Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors J.Med.Chem., 52:3689-3702, 2009 Cited by PubMed: 19358611 DOI: 10.1021/jm900022f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation