3FZ1

Crystal structure of a benzthiophene inhibitor bound to human Cyclin-dependent Kinase-2 (CDK-2)

Summary for 3FZ1

Entry DOI	10.2210/pdb3fz1/pdb
Related	1AQ1 3FYK
Descriptor	Cell division protein kinase 2, (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one (3 entities in total)
Functional Keywords	cdk-2, mk-2, mk2, mapkap kinase-2, ser/thr kinase, cell divison kinase-2, cyclin, benzothiophene, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Total number of polymer chains	1
Total formula weight	34253.83
Authors	Kurumbail, R.G.,Caspers, N. (deposition date: 2009-01-23, release date: 2009-04-07, Last modification date: 2023-09-06)
Primary citation	Anderson, D.R.,Meyers, M.J.,Kurumbail, R.G.,Caspers, N.,Poda, G.I.,Long, S.A.,Pierce, B.S.,Mahoney, M.W.,Mourey, R.J.,Parikh, M.D. Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency. Bioorg.Med.Chem.Lett., 19:4882-4884, 2009 Cited by PubMed: 19616942 DOI: 10.1016/j.bmcl.2009.02.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation