3FYK

Crystal structure of a benzthiophene lead bound to MAPKAP Kinase-2 (MK-2)

Summary for 3FYK

Entry DOI	10.2210/pdb3fyk/pdb
Related	2P3G 3FYJ
Descriptor	MAP kinase-activated protein kinase 2, (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one (2 entities in total)
Functional Keywords	mk-2, mk2, mapkap-2, ser/thr kinase, map kinase, alternative splicing, atp-binding, kinase, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P49137
Total number of polymer chains	1
Total formula weight	38175.09
Authors	Kurumbail, R.G.,Caspers, N. (deposition date: 2009-01-22, release date: 2009-04-07, Last modification date: 2023-09-06)
Primary citation	Anderson, D.R.,Meyers, M.J.,Kurumbail, R.G.,Caspers, N.,Poda, G.I.,Long, S.A.,Pierce, B.S.,Mahoney, M.W.,Mourey, R.J.,Parikh, M.D. Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency. Bioorg.Med.Chem.Lett., 19:4882-4884, 2009 Cited by PubMed: 19616942 DOI: 10.1016/j.bmcl.2009.02.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation