3FUP

Crystal structures of JAK1 and JAK2 inhibitor complexes

Summary for 3FUP

Entry DOI	10.2210/pdb3fup/pdb
Related	2B7A 3EYG 3EYH
Descriptor	Tyrosine-protein kinase JAK2, 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile (3 entities in total)
Functional Keywords	kinase, ptk domain, protein-inhibitor complex, atp-binding, chromosomal rearrangement, disease mutation, membrane, nucleotide-binding, phosphoprotein, polymorphism, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	69809.51
Authors	Williams, N.K.,Bamert, R.S.,Patel, O.,Fantino, E.,Rossjohn, J.,Lucet, I.S. (deposition date: 2009-01-14, release date: 2009-02-10, Last modification date: 2023-11-22)
Primary citation	Williams, N.K.,Bamert, R.S.,Patel, O.,Wang, C.,Walden, P.M.,Wilks, A.F.,Fantino, E.,Rossjohn, J.,Lucet, I.S. Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. J.Mol.Biol., 387:219-232, 2009 Cited by PubMed: 19361440 DOI: 10.1016/j.jmb.2009.01.041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation