2B7A

The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

Summary for 2B7A

• Entry DOI: 10.2210/pdb2b7a/pdb
• Descriptor: Tyrosine-protein kinase JAK2, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE (3 entities in total)
• Functional Keywords: kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Endomembrane system ; Peripheral membrane protein : O60674
• Total number of polymer chains: 2
• Total formula weight: 69803.44

Authors

Lucet, I.S.,Fantino, E.,Styles, M.,Bamert, R.,Patel, O.,Broughton, S.E.,Walter, M.,Burns, C.J.,Treutlein, H.,Wilks, A.F.,Rossjohn, J. (deposition date: 2005-10-04, release date: 2006-01-10, Last modification date: 2023-11-15)

• Primary citation: Lucet, I.S.,Fantino, E.,Styles, M.,Bamert, R.,Patel, O.,Broughton, S.E.,Walter, M.,Burns, C.J.,Treutlein, H.,Wilks, A.F.,Rossjohn, J.; The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor.; Blood, 107:176-183, 2006; PubMed: 16174768; DOI: 10.1182/blood-2005-06-2413

Experimental method

X-RAY DIFFRACTION (2 Å)