3FQH
Crystal structure of spleen tyrosine kinase complexed with a 2-substituted 7-azaindole
Summary for 3FQH
Entry DOI | 10.2210/pdb3fqh/pdb |
Related | 3FQE 3FQS |
Descriptor | Tyrosine-protein kinase SYK, N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide (3 entities in total) |
Functional Keywords | syk, spleen typrosine kinase, kinase inhibitor, 7-azaindole, alternative splicing, atp-binding, host-virus interaction, kinase, nucleotide-binding, phosphoprotein, polymorphism, sh2 domain, transferase, tyrosine-protein kinase, ubl conjugation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 68492.86 |
Authors | Kuglstatter, A.,Villasenor, A.G. (deposition date: 2009-01-07, release date: 2009-03-10, Last modification date: 2023-09-06) |
Primary citation | Villasenor, A.G.,Kondru, R.,Ho, H.,Wang, S.,Papp, E.,Shaw, D.,Barnett, J.W.,Browner, M.F.,Kuglstatter, A. Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes. Chem.Biol.Drug Des., 73:466-470, 2009 Cited by PubMed: 19220318DOI: 10.1111/j.1747-0285.2009.00785.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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