3FQS

Crystal structure of spleen tyrosine kinase complexed with R406

Summary for 3FQS

Entry DOI	10.2210/pdb3fqs/pdb
Related	3FQE 3FQH
Descriptor	Tyrosine-protein kinase SYK, 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (3 entities in total)
Functional Keywords	syk, spleen typrosine kinase, kinase inhibitor, r406, r788, amino-pyrimidine, atp-binding, host-virus interaction, kinase, nucleotide-binding, phosphoprotein, sh2 domain, transferase, tyrosine-protein kinase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34354.46
Authors	Kuglstatter, A.,Villasenor, A.G. (deposition date: 2009-01-07, release date: 2009-03-10, Last modification date: 2023-09-06)
Primary citation	Villasenor, A.G.,Kondru, R.,Ho, H.,Wang, S.,Papp, E.,Shaw, D.,Barnett, J.W.,Browner, M.F.,Kuglstatter, A. Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes. Chem.Biol.Drug Des., 73:466-470, 2009 Cited by PubMed: 19220318 DOI: 10.1111/j.1747-0285.2009.00785.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation