Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3EMG

Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

Summary for 3EMG
Entry DOI10.2210/pdb3emg/pdb
DescriptorTyrosine-protein kinase SYK, 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide (3 entities in total)
Functional Keywordskinase, syk, alternative splicing, atp-binding, host-virus interaction, nucleotide-binding, phosphoprotein, polymorphism, sh2 domain, transferase, tyrosine-protein kinase, ubl conjugation
Biological sourceHomo sapiens
Total number of polymer chains1
Total formula weight34106.22
Authors
Ter Haar, E. (deposition date: 2008-09-24, release date: 2008-12-02, Last modification date: 2024-02-21)
Primary citationFarmer, L.J.,Bemis, G.,Britt, S.D.,Cochran, J.,Connors, M.,Harrington, E.M.,Hoock, T.,Markland, W.,Nanthakumar, S.,Taslimi, P.,Ter Haar, E.,Wang, J.,Zhaveri, D.,Salituro, F.G.
Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK).
Bioorg.Med.Chem.Lett., 18:6231-6235, 2008
Cited by
PubMed: 18938080
DOI: 10.1016/j.bmcl.2008.09.106
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon