3EMG
Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase SYK | polymer | 291 | 33708.7 | 1 | UniProt (P43405) Pfam (PF07714) In PDB | Homo sapiens | Spleen tyrosine kinase |
| 2 | A | 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide | non-polymer | 397.5 | 1 | Chemie (685) | |||
| 3 | water | water | 18.0 | 83 | Chemie (HOH) |
Sequence modifications
A: 349 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| Gly 345 | - | expression tag |
| Ser 346 | - | expression tag |
| Leu 347 | - | expression tag |
| His 348 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33708.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 397.5 | |
| All* | Total formula weight | 34106.2 |
