3DZ3
Human AdoMetDC F223A mutant with covalently bound S-Adenosylmethionine methyl ester
Summary for 3DZ3
Entry DOI | 10.2210/pdb3dz3/pdb |
Related | 1I72 1I79 1I7B 1I7C 1I7M 1JEN 3DZ2 3DZ4 3DZ5 3DZ6 3DZ7 |
Descriptor | S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, 1,4-DIAMINOBUTANE, ... (5 entities in total) |
Functional Keywords | complexes of adometdc with 8-substituted ligands, decarboxylase, lyase, pyruvate, s-adenosyl-l-methionine, spermidine biosynthesis, zymogen |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 38807.10 |
Authors | Bale, S.,McCloskey, D.E.,Pegg, A.E.,Secrist III, J.A.,Guida, W.C.,Ealick, S.E. (deposition date: 2008-07-29, release date: 2009-03-10, Last modification date: 2023-11-15) |
Primary citation | McCloskey, D.E.,Bale, S.,Secrist III, J.A.,Tiwari, A.,Moss III, T.H.,Valiyaveettil, J.,Brooks, W.H.,Guida, W.C.,Pegg, A.E.,Ealick, S.E. New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine J.Med.Chem., 52:1388-1407, 2009 Cited by PubMed: 19209891DOI: 10.1021/jm801126a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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