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3DZ7

Human AdoMetDC with 5'-[(carboxamidomethyl)methylamino]-5'-deoxy-8-methyladenosine

Summary for 3DZ7
Entry DOI10.2210/pdb3dz7/pdb
Related1I72 1I79 1I7B 1I7C 1I7M 1JEN 3DZ2 3DZ3 3DZ4 3DZ5 3DZ6
DescriptorS-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, 1,4-DIAMINOBUTANE, ... (5 entities in total)
Functional Keywordscomplexes of adometdc with 8-substituted ligands, decarboxylase, lyase, pyruvate, s-adenosyl-l-methionine, spermidine biosynthesis, zymogen, ligase
Biological sourceHomo sapiens (human)
More
Total number of polymer chains2
Total formula weight38820.08
Authors
Bale, S.,McCloskey, D.E.,Pegg, A.E.,Secrist III, J.A.,Guida, W.C.,Ealick, S.E. (deposition date: 2008-07-29, release date: 2009-03-10, Last modification date: 2023-11-15)
Primary citationMcCloskey, D.E.,Bale, S.,Secrist III, J.A.,Tiwari, A.,Moss III, T.H.,Valiyaveettil, J.,Brooks, W.H.,Guida, W.C.,Pegg, A.E.,Ealick, S.E.
New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine
J.Med.Chem., 52:1388-1407, 2009
Cited by
PubMed: 19209891
DOI: 10.1021/jm801126a
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.91 Å)
Structure validation

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