3DBH
Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190Ala-NEDD8Ala72Arg)
Summary for 3DBH
Entry DOI | 10.2210/pdb3dbh/pdb |
Related | 1R4M 1R4N 1YOV 3DBL 3DBR |
Descriptor | NEDD8-activating enzyme E1 regulatory subunit, NEDD8-activating enzyme E1 catalytic subunit, NEDD8, ... (4 entities in total) |
Functional Keywords | cell cycle, activating enzyme, apoptosis, membrane, ubl conjugation pathway, atp-binding, ligase, nucleotide-binding, polymorphism, nucleus |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane: Q13564 Nucleus: Q15843 |
Total number of polymer chains | 12 |
Total formula weight | 473768.12 |
Authors | Souphron, J.,Schulman, B.A. (deposition date: 2008-05-31, release date: 2008-08-12, Last modification date: 2023-08-30) |
Primary citation | Souphron, J.,Waddell, M.B.,Paydar, A.,Tokgoz-Gromley, Z.,Roussel, M.F.,Schulman, B.A. Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. Biochemistry, 47:8961-8969, 2008 Cited by PubMed: 18652489DOI: 10.1021/bi800604c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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