3DBR

Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190Gln-NEDD8Ala72Arg)

Summary for 3DBR

Entry DOI	10.2210/pdb3dbr/pdb
Related	1R4M 1R4N 1YOV 3DBH 3DBL
Descriptor	NEDD8-activating enzyme E1 regulatory subunit, NEDD8-activating enzyme E1 catalytic subunit, NEDD8, ... (4 entities in total)
Functional Keywords	cell cycle, activating enzyme, apoptosis, membrane, ubl conjugation pathway, atp-binding, ligase, nucleotide-binding, polymorphism, nucleus
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane: Q13564 Nucleus: Q15843
Total number of polymer chains	12
Total formula weight	473996.33
Authors	Souphron, J.,Schulman, B.A. (deposition date: 2008-06-02, release date: 2008-08-12, Last modification date: 2023-08-30)
Primary citation	Souphron, J.,Waddell, M.B.,Paydar, A.,Tokgoz-Gromley, Z.,Roussel, M.F.,Schulman, B.A. Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. Biochemistry, 47:8961-8969, 2008 Cited by PubMed: 18652489 DOI: 10.1021/bi800604c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.05 Å)

Structure validation