3D2T
Human transthyretin (ttr) complexed with diflunisal
Summary for 3D2T
Entry DOI | 10.2210/pdb3d2t/pdb |
Related | 1BMZ 2B77 2B9A 2F7I |
Descriptor | Transthyretin, 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID (3 entities in total) |
Functional Keywords | ttr, amyloid, transthyretin, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a, hormone-growth factor complex |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28055.12 |
Authors | Palaninathan, S.K.,Kelly, J.W.,Sacchettini, J.C. (deposition date: 2008-05-08, release date: 2008-05-20, Last modification date: 2023-08-30) |
Primary citation | Adamski-Werner, S.L.,Palaninathan, S.K.,Sacchettini, J.C.,Kelly, J.W. Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. J.Med.Chem., 47:355-374, 2004 Cited by PubMed: 14711308DOI: 10.1021/jm030347n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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