2B77
Human transthyretin (TTR) complexed with Diflunisal analogues- TTR.2',4'-DICHLORO-4-HYDROXY-1,1'-BIPHENYL-3-CARBOXYLIC ACID
Summary for 2B77
| Entry DOI | 10.2210/pdb2b77/pdb |
| Related | 1BM7 1DVQ 1DVS 1DVT 1DVX 1DVY 1bmz |
| Descriptor | Transthyretin, 2',4'-DICHLORO-4-HYDROXY-1,1'-BIPHENYL-3-CARBOXYLIC ACID (3 entities in total) |
| Functional Keywords | ttr, amyloid, transthyretin, hormone-growth factor complex, hormone/growth factor |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted: P02766 |
| Total number of polymer chains | 2 |
| Total formula weight | 28120.93 |
| Authors | Palaninathan, S.K.,Kelly, J.W.,Sacchettini, J.C. (deposition date: 2005-10-03, release date: 2005-10-11, Last modification date: 2023-08-23) |
| Primary citation | Adamski-Werner, S.L.,Palaninathan, S.K.,Sacchettini, J.C.,Kelly, J.W. Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. J.Med.Chem., 47:355-374, 2004 Cited by PubMed: 14711308DOI: 10.1021/jm030347n PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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