3COT
Crystal structure of human liver delta(4)-3-ketosteroid 5beta-reductase (akr1d1) in complex with progesterone and nadp. Resolution: 2.03 A.
Summary for 3COT
| Entry DOI | 10.2210/pdb3cot/pdb |
| Related | 3CMF |
| Descriptor | 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE, ... (4 entities in total) |
| Functional Keywords | steroid c-c double bond reduction, 5beta reductase, e120, bile acid catabolism, cytoplasm, disease mutation, lipid metabolism, nadp, oxidoreductase, steroid metabolism |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P51857 |
| Total number of polymer chains | 2 |
| Total formula weight | 81314.25 |
| Authors | Di Costanzo, L.,Drury, J.,Penning, T.M.,Christianson, D.W. (deposition date: 2008-03-29, release date: 2008-04-08, Last modification date: 2023-08-30) |
| Primary citation | Di Costanzo, L.,Drury, J.E.,Penning, T.M.,Christianson, D.W. Crystal Structure of Human Liver {Delta}4-3-Ketosteroid 5{beta}-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis. J.Biol.Chem., 283:16830-16839, 2008 Cited by PubMed: 18407998DOI: 10.1074/jbc.M801778200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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