3CMF
Crystal structure of human liver 5beta-reductase (AKR1D1) in complex with NADP and CORTISONE. Resolution 1.90 A.
Summary for 3CMF
Entry DOI | 10.2210/pdb3cmf/pdb |
Related | 3BUR 3COT |
Descriptor | 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE, ... (4 entities in total) |
Functional Keywords | c-c double bond reduction, cortisone, akr1d1, steroid, bile acid catabolism, cytoplasm, disease mutation, lipid metabolism, nadp, oxidoreductase, steroid metabolism |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P51857 |
Total number of polymer chains | 2 |
Total formula weight | 81402.18 |
Authors | Di Costanzo, L.,Drury, J.,Penning, T.M.,Christianson, D.W. (deposition date: 2008-03-21, release date: 2008-04-08, Last modification date: 2023-08-30) |
Primary citation | Di Costanzo, L.,Drury, J.E.,Penning, T.M.,Christianson, D.W. Crystal Structure of Human Liver {Delta}4-3-Ketosteroid 5{beta}-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis. J.Biol.Chem., 283:16830-16839, 2008 Cited by PubMed: 18407998DOI: 10.1074/jbc.M801778200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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