3COJ
Crystal Structure of the BRCT Domains of Human BRCA1 in Complex with a Phosphorylated Peptide from Human Acetyl-CoA Carboxylase 1
Summary for 3COJ
Entry DOI | 10.2210/pdb3coj/pdb |
Related | 1T15 1T29 1T2V 1Y98 2AZM |
Descriptor | Breast cancer type 1 susceptibility protein, Acetyl-CoA carboxylase 1 (2 entities in total) |
Functional Keywords | breast cancer, ovarian cancer, fatty acid biosynthesis, lipid synthesis, obesity, protein-peptide complex, protein protein interaction, anti-oncogene, cell cycle, disease mutation, dna damage, dna repair, dna-binding, metal-binding, nucleus, phosphoprotein, zinc-finger, alternative promoter usage, atp-binding, biotin, ligase, manganese, multifunctional enzyme, nucleotide-binding, antitumor protein-ligase complex, antitumor protein/ligase |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398 Cytoplasm: Q13085 |
Total number of polymer chains | 16 |
Total formula weight | 225945.22 |
Authors | |
Primary citation | Shen, Y.,Tong, L. Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1 Biochemistry, 47:5767-5773, 2008 Cited by PubMed: 18452305DOI: 10.1021/bi800314m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.21 Å) |
Structure validation
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