2AZM
Crystal structure of the MDC1 brct repeat in complex with the histone tail of gamma-H2AX
Summary for 2AZM
| Entry DOI | 10.2210/pdb2azm/pdb |
| Descriptor | Mediator of DNA damage checkpoint protein 1, GAMMA-H2AX HISTONE (3 entities in total) |
| Functional Keywords | brct repeat, protein-phosphopeptide complex, dna damage, cell cycle |
| Biological source | Homo sapiens (human) More |
| Cellular location | Nucleus: Q14676 |
| Total number of polymer chains | 4 |
| Total formula weight | 48240.40 |
| Authors | Clapperton, J.A.,Stucki, M.,Mohammad, D.,Yaffe, M.B.,Jackson, S.P.,Smerdon, S.J. (deposition date: 2005-09-12, release date: 2006-01-31, Last modification date: 2011-07-13) |
| Primary citation | Stucki, M.,Clapperton, J.A.,Mohammad, D.,Yaffe, M.B.,Smerdon, S.J.,Jackson, S.P. MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks Cell(Cambridge,Mass.), 123:1213-1226, 2005 Cited by PubMed: 16377563DOI: 10.1016/j.cell.2005.09.038 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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