3BMQ
Structure of Pteridine Reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (Compound AX5)
Summary for 3BMQ
Entry DOI | 10.2210/pdb3bmq/pdb |
Related | 2C7V 3BMC 3BMD 3BME 3BMF 3BMG 3BMH 3BMI 3BMJ 3BMK 3BML 3BMM 3BMN 3BMO 3BMR 3BMS 3BMT |
Descriptor | Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-(benzylsulfanyl)pyrimidine-2,4-diamine, ... (8 entities in total) |
Functional Keywords | pteridine reductase, ptr1, trypanosoma brucei, short chain dehydrogenase, inhibitor, oxidoreductase |
Biological source | Trypanosoma brucei brucei More |
Total number of polymer chains | 4 |
Total formula weight | 127316.87 |
Authors | Martini, V.P.,Iulek, J.,Hunter, W.N. (deposition date: 2007-12-13, release date: 2008-12-16, Last modification date: 2011-07-13) |
Primary citation | Tulloch, L.B.,Martini, V.P.,Iulek, J.,Huggan, J.K.,Lee, J.H.,Gibson, C.L.,Smith, T.K.,Suckling, C.J.,Hunter, W.N. Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases. J.Med.Chem., 53:221-229, 2010 Cited by PubMed: 19916554DOI: 10.1021/jm901059x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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