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2C7V

Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate

Summary for 2C7V
Entry DOI10.2210/pdb2c7v/pdb
DescriptorPTERIDINE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (6 entities in total)
Functional Keywordspteridine reductase, trypanosomatids, drug resistance, short-chain dehydrogenase/reductase, methotrexate resistance, oxidoreductase
Biological sourceTRYPANOSOMA BRUCEI BRUCEI
Total number of polymer chains4
Total formula weight119980.47
Authors
Dawson, A.,Gibellini, F.,Sienkiewicz, N.,Fyfe, P.K.,McLuskey, K.,Fairlamb, A.H.,Hunter, W.N. (deposition date: 2005-11-29, release date: 2006-09-19, Last modification date: 2023-12-13)
Primary citationDawson, A.,Gibellini, F.,Sienkiewicz, N.,Tulloch, L.B.,Fyfe, P.K.,Mcluskey, K.,Fairlamb, A.H.,Hunter, W.N.
Structure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition by the Archetypal Antifolate Methotrexate
Mol.Microbiol., 61:1457-, 2006
Cited by
PubMed: 16968221
DOI: 10.1111/J.1365-2958.2006.05332.X
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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