3BGR
Crystal structure of K103N/Y181C mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (Rilpivirine), a non-nucleoside RT inhibitor
Summary for 3BGR
Entry DOI | 10.2210/pdb3bgr/pdb |
Related | 1S6Q 1SV5 2IC3 2ZD1 2ZE2 |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (5 entities in total) |
Functional Keywords | p51/p66, hetero dimer, nnrti, nonnucleoside inhibitor, aids, hiv, r278474, rilpivirine, diarylpyrimidine, dapy, dna recombination, rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase, k103n, y181c |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 114382.10 |
Authors | Das, K.,Bauman, J.D.,Clark Jr., A.D.,Shatkin, A.J.,Arnold, E. (deposition date: 2007-11-27, release date: 2008-02-12, Last modification date: 2023-11-01) |
Primary citation | Das, K.,Bauman, J.D.,Clark Jr., A.D.,Frenkel, Y.V.,Lewi, P.J.,Shatkin, A.J.,Hughes, S.H.,Arnold, E. High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations. Proc.Natl.Acad.Sci.Usa, 105:1466-1471, 2008 Cited by PubMed: 18230722DOI: 10.1073/pnas.0711209105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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