2ZE2

Crystal structure of L100I/K103N mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (rilpivirine), a non-nucleoside RT inhibitor

Summary for 2ZE2

• Entry DOI: 10.2210/pdb2ze2/pdb
• Related: 1S6Q 1SV5 2IC3 2ZD1 3BGR
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile (3 entities in total)
• Functional Keywords: p51/p66, hetero dimer, nnrti, nonnucleoside inhibitor, aids, hiv, r278474, rilpivirine, diarylpyrimidine, dapy, dna recombination, rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• Total number of polymer chains: 2
• Total formula weight: 114380.07

Authors

Das, K.,Bauman, J.D.,Clark Jr., A.D.,Shatkin, A.J.,Arnold, E. (deposition date: 2007-12-05, release date: 2008-02-12, Last modification date: 2023-11-01)

• Primary citation: Das, K.,Bauman, J.D.,Clark Jr., A.D.,Frenkel, Y.V.,Lewi, P.J.,Shatkin, A.J.,Hughes, S.H.,Arnold, E.; High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations.; Proc.Natl.Acad.Sci.Usa, 105:1466-1471, 2008; PubMed: 18230722; DOI: 10.1073/pnas.0711209105

Experimental method

X-RAY DIFFRACTION (2.9 Å)