3AO5
Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase
Summary for 3AO5
Entry DOI | 10.2210/pdb3ao5/pdb |
Related | 1bl3 3AO1 3AO2 3AO3 3AO4 3L3U 3OVN |
Related PRD ID | PRD_900003 |
Descriptor | POL polyprotein, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, 5-(7-bromo-1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazol-3-amine, ... (7 entities in total) |
Functional Keywords | dna integration, aids, integrase, endonuclease, polynucleotidyl transferase, dna binding, viral protein, rnaseh, fragment binding, viral protein-transferase inhibitor complex, viral protein/transferase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 37571.74 |
Authors | Wielens, J.,Headey, S.J.,Parker, M.W.,Chalmers, D.K.,Scanlon, M.J. (deposition date: 2010-09-21, release date: 2011-03-09, Last modification date: 2023-11-01) |
Primary citation | Wielens, J.,Headey, S.J.,Deadman, J.J.,Rhodes, D.I.,Parker, M.W.,Chalmers, D.K.,Scanlon, M.J. Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6:258-261, 2011 Cited by PubMed: 21275048DOI: 10.1002/cmdc.201000483 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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