3A2I

Crystal structure of the human vitamin D receptor (H305F) ligand binding domain complexed with TEI-9647

Summary for 3A2I

Entry DOI	10.2210/pdb3a2i/pdb
Related	3A2H 3A2J
Descriptor	Vitamin D3 receptor, (1S,3R,5Z,7E,20S,23S)-1,3-dihydroxy-23,26-epoxy-9,10-secocholesta-5,7,10,25(27)-tetraen-26-one (2 entities in total)
Functional Keywords	hormone/growth factor receptor, dna-binding, metal-binding, nucleus, phosphoprotein, transcription, transcription regulation, zinc-finger, activator, disease mutation, receptor, hormone receptor
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P11473
Total number of polymer chains	1
Total formula weight	30240.95
Authors	Kakuda, S.,Takimoto-Kamimura, M. (deposition date: 2009-05-20, release date: 2010-05-26, Last modification date: 2023-11-01)
Primary citation	Kakuda, S.,Ishizuka, S.,Eguchi, H.,Mizwicki, M.T.,Norman, A.W.,Takimoto-Kamimura, M. Structural basis of the histidine-mediated vitamin D receptor agonistic and antagonistic mechanisms of (23S)-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactone Acta Crystallogr.,Sect.D, 66:918-926, 2010 Cited by PubMed: 20693691 DOI: 10.1107/S0907444910020810 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.27 Å)

Structure validation