2ZVJ
Crystal structures of rat Catechol-O-Methyltransferase complexed with coumarine-based inhibitor
Summary for 2ZVJ
Entry DOI | 10.2210/pdb2zvj/pdb |
Related | 1H1D 1JR4 1VID 2CL5 |
Descriptor | Catechol O-methyltransferase, MAGNESIUM ION, S-ADENOSYLMETHIONINE, ... (5 entities in total) |
Functional Keywords | transferase, methyltransferase, neurotransmitter degradation, alternative initiation, catecholamine metabolism, cell membrane, cytoplasm, magnesium, membrane, metal-binding, phosphoprotein, s-adenosyl-l-methionine, signal-anchor, transmembrane |
Biological source | Rattus norvegicus (Rat) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734 |
Total number of polymer chains | 1 |
Total formula weight | 25593.51 |
Authors | Tsuji, E. (deposition date: 2008-11-07, release date: 2009-01-06, Last modification date: 2023-11-01) |
Primary citation | Tsuji, E.,Okazaki, K.,Takeda, K. Crystal structures of rat catechol-O-methyltransferase complexed with coumarine-based inhibitor Biochem.Biophys.Res.Commun., 378:494-497, 2009 Cited by PubMed: 19056347DOI: 10.1016/j.bbrc.2008.11.085 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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