2CL5

Catechol-O-methyltransferase in complex with an inhibitor

Summary for 2CL5

Entry DOI	10.2210/pdb2cl5/pdb
Descriptor	CATECHOL O-METHYLTRANSFERASE, MAGNESIUM ION, S-ADENOSYLMETHIONINE, ... (7 entities in total)
Functional Keywords	transferase, alternative initiation, catecholamine metabolism, neurotransmitter degradation, catechol-o-methyltransferase, phosphorylation, methyltransferase, signal-anchor, transmembrane, comt inhibitor, membrane, magnesium, metal-binding
Biological source	RATTUS NORVEGICUS (RAT)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
Total number of polymer chains	2
Total formula weight	51374.31
Authors	Palma, P.N.,Rodrigues, M.L.,Archer, M.,Bonifacio, M.J.,Loureiro, A.I.,Learmonth, D.A.,Carrondo, M.A.,Soares-Da-Silva, P. (deposition date: 2006-04-26, release date: 2006-06-28, Last modification date: 2023-12-13)
Primary citation	Palma, P.N.,Rodrigues, M.L.,Archer, M.,Bonifacio, M.J.,Loureiro, A.I.,Learmonth, D.A.,Carrondo, M.A.,Soares-Da-Silva, P. Comparative Study of Ortho- and Meta-Nitrated Inhibitors of Catechol-O-Methyltransferase: Interactions with the Active Site and Regioselectivity of O-Methylation. Mol.Pharmacol., 70:143-, 2006 Cited by PubMed: 16618795 DOI: 10.1124/MOL.106.023119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation