2YDE
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH S-2-HYDROXYGLUTARATE
Summary for 2YDE
Entry DOI | 10.2210/pdb2yde/pdb |
Related | 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 |
Descriptor | HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (III) ION, (2S)-2-HYDROXYPENTANEDIOIC ACID, ... (6 entities in total) |
Functional Keywords | oxidoreductase, non-heme iron, dioxygenase, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, asparaginyl/ aspartyl hydroxylase, ankyrin repeat domain, ard, beta-hydroxylation, transcription activator/inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 41531.06 |
Authors | Chowdhury, R.,Clifton, I.J.,Schofield, C.J. (deposition date: 2011-03-18, release date: 2011-03-30, Last modification date: 2023-12-20) |
Primary citation | Chowdhury, R.,Yeoh, K.K.,Tian, Y.M.,Hillringhaus, L.,Bagg, E.A.,Rose, N.R.,Leung, I.K.,Li, X.S.,Woon, E.C.,Yang, M.,McDonough, M.A.,King, O.N.,Clifton, I.J.,Klose, R.J.,Claridge, T.D.,Ratcliffe, P.J.,Schofield, C.J.,Kawamura, A. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep., 12:463-469, 2011 Cited by PubMed: 21460794DOI: 10.1038/embor.2011.43 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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