2XNP
Structure of Nek2 bound to CCT244858
Summary for 2XNP
Entry DOI | 10.2210/pdb2xnp/pdb |
Related | 2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO |
Descriptor | SERINE/THREONINE-PROTEIN KINASE NEK2, 4-{5-[(1-METHYLPIPERIDIN-4-YL)OXY]-1H-BENZIMIDAZOL-1-YL}-2-{(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY}BENZAMIDE, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | transferase, centrosome, mitosis, cell cycle |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus. Isoform 1: Nucleus, nucleolus. Isoform 2: Cytoplasm: P51955 |
Total number of polymer chains | 1 |
Total formula weight | 33653.19 |
Authors | Mas-Droux, C.,Bayliss, R. (deposition date: 2010-08-05, release date: 2011-03-30, Last modification date: 2023-12-20) |
Primary citation | Solanki, S.,Innocenti, P.,Mas-Droux, C.,Boxall, K.,Barillari, C.,Van Montfort, R.L.,Aherne, G.W.,Bayliss, R.,Hoelder, S. Benzimidazole Inhibitors Induce a Dfg-Out Conformation of Never in Mitosis Gene A-Related Kinase 2 (Nek2) without Binding to the Back Pocket and Reveal a Nonlinear Structure-Activity Relationship. J.Med.Chem., 54:1626-, 2011 Cited by PubMed: 21366329DOI: 10.1021/JM1011726 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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