2WGH

Human Ribonucleotide reductase R1 subunit (RRM1) in complex with dATP and Mg.

Summary for 2WGH

• Entry DOI: 10.2210/pdb2wgh/pdb
• Descriptor: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT, GLYCEROL, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: dna replication, allosteric enzyme, nucleotide-binding, cytoplasm, atp-binding, polymorphism, oxidoreductase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: P23921
• Total number of polymer chains: 2
• Total formula weight: 155451.02

Authors

Welin, R.M.,Moche, M.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Karlberg, T.,Kragh-Nielsen, T.,Kotzsch, A.,Kotenyova, T.,Nyman, T.,Persson, C.,Sagemark, J.,Schueler, H.,Schutz, P.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Weigelt, J.,Wisniewska, M.,Nordlund, P. (deposition date: 2009-04-19, release date: 2009-05-05, Last modification date: 2023-12-13)

• Primary citation: Fairman, J.W.,Wijerathna, S.R.,Ahmad, M.F.,Xu, H.,Nakano, R.,Jha, S.,Prendergast, J.,Welin, R.M.,Flodin, S.,Roos, A.,Nordlund, P.,Li, Z.,Walz, T.,Dealwis, C.G.; Structural Basis for Allosteric Regulation of Human Ribonucleotide Reductase by Nucleotide-Induced Oligomerization.; Nat.Struct.Mol.Biol., 18:316-, 2011; PubMed: 21336276; DOI: 10.1038/NSMB.2007

Experimental method

X-RAY DIFFRACTION (2.3 Å)